Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease.
Identifieur interne : 002925 ( Main/Exploration ); précédent : 002924; suivant : 002926Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease.
Auteurs : B G Feagan [Canada] ; W J Sandborn [États-Unis] ; G. D'Haens [Pays-Bas] ; S D Lee [États-Unis] ; M. Allez [France] ; R N Fedorak [Canada] ; U. Seidler [Allemagne] ; S. Vermeire [Belgique] ; I C Lawrance [Australie] ; A C Maroney [États-Unis] ; C H Jurgensen [États-Unis] ; A. Heath [États-Unis] ; D J Chang [États-Unis]Source :
- Alimentary pharmacology & therapeutics [ 1365-2036 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Complexe antigénique L1 leucocytaire (métabolisme), Femelle, Fèces, Humains, Jeune adulte, Maladie de Crohn (traitement médicamenteux), Mâle, Méthode en double aveugle, Protéine C-réactive (métabolisme), Récepteurs CCR (antagonistes et inhibiteurs), Sulfonamides (usage thérapeutique).
- MESH :
- antagonistes et inhibiteurs : Récepteurs CCR.
- métabolisme : Complexe antigénique L1 leucocytaire, Protéine C-réactive.
- traitement médicamenteux : Maladie de Crohn.
- usage thérapeutique : Sulfonamides.
- Adulte, Adulte d'âge moyen, Femelle, Fèces, Humains, Jeune adulte, Mâle, Méthode en double aveugle.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Receptors, CCR.
- chemical , metabolism : C-Reactive Protein, Leukocyte L1 Antigen Complex.
- drug therapy : Crohn Disease.
- chemical , therapeutic use : Sulfonamides.
- Adult, Double-Blind Method, Feces, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Many patients with active Crohn's disease do not adequately respond to therapies, highlighting the need for new treatments.
DOI: 10.1111/apt.13398
PubMed: 26400458
Affiliations:
- Allemagne, Australie, Belgique, Canada, France, Pays-Bas, États-Unis
- Basse-Saxe, Californie, Hollande-Septentrionale, Pennsylvanie, Washington (État), Île-de-France
- Amsterdam, Hanovre, Paris, Seattle
- Université de Washington
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002727
- to stream PubMed, to step Curation: 002658
- to stream PubMed, to step Checkpoint: 002658
- to stream Ncbi, to step Merge: 002B06
- to stream Ncbi, to step Curation: 002B06
- to stream Ncbi, to step Checkpoint: 002B06
- to stream Main, to step Merge: 002925
- to stream Main, to step Curation: 002925
Le document en format XML
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Heath</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, King of Prussia, PA, Research Triangle Park, NC, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, King of Prussia, PA, Research Triangle Park, NC, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Chang, D J" sort="Chang, D J" uniqKey="Chang D" first="D J" last="Chang">D J Chang</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, King of Prussia, PA, Research Triangle Park, NC, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, King of Prussia, PA, Research Triangle Park, NC, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Alimentary pharmacology & therapeutics</title><idno type="eISSN">1365-2036</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>C-Reactive Protein (metabolism)</term><term>Crohn Disease (drug therapy)</term><term>Double-Blind Method</term><term>Feces</term><term>Female</term><term>Humans</term><term>Leukocyte L1 Antigen Complex (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Receptors, CCR (antagonists & inhibitors)</term><term>Sulfonamides (therapeutic use)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Complexe antigénique L1 leucocytaire (métabolisme)</term><term>Femelle</term><term>Fèces</term><term>Humains</term><term>Jeune adulte</term><term>Maladie de Crohn (traitement médicamenteux)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Protéine C-réactive (métabolisme)</term><term>Récepteurs CCR (antagonistes et inhibiteurs)</term><term>Sulfonamides (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptors, CCR</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term><term>Leukocyte L1 Antigen Complex</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteurs CCR</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexe antigénique L1 leucocytaire</term><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie de Crohn</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Sulfonamides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Feces</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Fèces</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many patients with active Crohn's disease do not adequately respond to therapies, highlighting the need for new treatments.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Californie</li><li>Hollande-Septentrionale</li><li>Pennsylvanie</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Hanovre</li><li>Paris</li><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Feagan, B G" sort="Feagan, B G" uniqKey="Feagan B" first="B G" last="Feagan">B G Feagan</name></noRegion><name sortKey="Fedorak, R N" sort="Fedorak, R N" uniqKey="Fedorak R" first="R N" last="Fedorak">R N Fedorak</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Sandborn, W J" sort="Sandborn, W J" uniqKey="Sandborn W" first="W J" last="Sandborn">W J Sandborn</name></region><name sortKey="Chang, D J" sort="Chang, D J" uniqKey="Chang D" first="D J" last="Chang">D J Chang</name><name sortKey="Heath, A" sort="Heath, A" uniqKey="Heath A" first="A" last="Heath">A. Heath</name><name sortKey="Jurgensen, C H" sort="Jurgensen, C H" uniqKey="Jurgensen C" first="C H" last="Jurgensen">C H Jurgensen</name><name sortKey="Lee, S D" sort="Lee, S D" uniqKey="Lee S" first="S D" last="Lee">S D Lee</name><name sortKey="Maroney, A C" sort="Maroney, A C" uniqKey="Maroney A" first="A C" last="Maroney">A C Maroney</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="D Haens, G" sort="D Haens, G" uniqKey="D Haens G" first="G" last="D'Haens">G. D'Haens</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Allez, M" sort="Allez, M" uniqKey="Allez M" first="M" last="Allez">M. Allez</name></region></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Seidler, U" sort="Seidler, U" uniqKey="Seidler U" first="U" last="Seidler">U. Seidler</name></region></country><country name="Belgique"><noRegion><name sortKey="Vermeire, S" sort="Vermeire, S" uniqKey="Vermeire S" first="S" last="Vermeire">S. Vermeire</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Lawrance, I C" sort="Lawrance, I C" uniqKey="Lawrance I" first="I C" last="Lawrance">I C Lawrance</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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